Hepatology[Jour]AND74[volume]ANDl[issue]
肝脏病学74卷1期
HepatologyHighlights（肝病学亮点）
1
HepatologyHighlights
肝病学亮点
AdamBuckholz,CatherineLucero,LaurenM.Yang,DarylT.Y.Lau,CesarTaborda,JoelWedd,EnisKostallari,RobertE.Schwartz,AdebowaleO.Bamidele,TejasavS.Sehrawat,AlysonKaplan,BrettE.Fortune,NabeelWahid,BrettE.Fortune,AnthonyJ.Choi,RobertS.BrownJr.,PetraHirsova,NidhiJalan-Sakrikar
Pages:1-4
Editorials（社论）
2
ExosomesandMicroRNA-attheIntersectionofInflammationandFibrosisinNAFLD
NAFLD炎症和纤维化交叉处的外泌体和MicroRNA-
GyongyiSzabo
Pages:5-8
3
ArtificialIntelligenceinNASHHistology:HumanTeachesaMachinefortheMachinetoHelpHumans
NASH组织学中的人工智能：人类教机器让机器帮助人类
MazenNoureddinM.D.,M.H.Sc.
Pages:9-11
IntroductionOftheAASLDPresident（AASLD主席介绍）
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IntroducingRaymondT.Chung,M.D.,OurAASLDPresident
介绍RaymondT.Chung,MD，我们的年AASLD主席
JulesL.DienstagM.D.
Pages:12-18
RapidCommunication（快速沟通）
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Pharmacokinetics,Safety,andEfficacyofGlecaprevir/PibrentasvirinChildrenWithChronicHCV:Part2oftheDORAStudy
Glecaprevir/Pibrentasvir在慢性HCV儿童中的药代动力学、安全性和有效性：DORA研究的第2部分
MaureenM.Jonas,SusanRhee,DeirdreA.Kelly,AntonioDelValle-Segarra,CorneliaFeiterna-Sperling,SusanGilmour,ReginoP.Gonzalez-Peralta,LoretoHierro,DanielH.Leung,SimonC.Ling,YuriLobzin,StevenLobritto,TatsukiMizuochi,MichaelR.Narkewicz,VishakhaSabharwal,JessicaWen,HoiKeiLon,JohnMarcinak,AndrewTopp,RakeshTripathi,EtienneSokal
Pages:19-27
OriginalArticles（原创文章）
ViralHepatitis（病*性肝炎）
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FactorsAssociatedWithHepatitisAMortalityDuringPerson-to-PersonOutbreaks:AMatchedCase–ControlStudy—UnitedStates,-
人与人之间爆发期间与甲型肝炎死亡率相关的因素：匹配病例对照研究——美国，-
MeganG.Hofmeister,JianXing,MoniqueA.Foster,RyanJ.Augustine,ColeBurkholder,JimCollins,ShannonMcBee,EricaD.Thomasson,DouglasThoroughman,MarkK.Weng,PhilipR.Spradling
Pages:28-40
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InhibitionofLongNoncodingRNALinc-PintbyHepatitisCVirusinInfectedHepatocytesEnhancesLipogenesis
丙型肝炎病*在感染肝细胞中抑制长链非编码RNALinc-Pint增强脂肪生成
MousumiKhatun,SubhayanSur,RobertSteele,RanjitRay,RatnaB.Ray
Pages:41-54
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TherapeuticPotentialofTLR8AgonistGS-(Selgantolimod)inChronicHepatitisB:RemodelingofAntiviralandRegulatoryMediators
TLR8激动剂GS-（Selgantolimod）在慢性乙型肝炎中的治疗潜力：抗病*和调节介质的重塑
OliverE.Amin,EmilyJ.Colbeck,StephaneDaffis,ShahzadaKhan,DhivyaRamakrishnan,DivyaPattabiraman,RuthChu,HollyMicolochickSteuer,SophieLehar,LeannePeiser,AdamPalazzo,ChristianFrey,JessicaDavies,HassanJavanbakht,WilliamM.C.Rosenberg,SimonP.Fletcher,MalaK.Maini,LauraJ.Pallett
Pages:55-71
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EradicationofChronicHCVInfection:ImprovementofDysbiosisOnlyinPatientsWithoutLiverCirrhosis
根除慢性HCV感染：仅改善非肝硬化患者的生态失调
FreyaWellh?ner,NicoD?scher,FranziskaWoelfl,MariusVital,IrisPlumeier,SilkeKahl,AndrejPotthoff,MichaelPeterManns,DietmarHelmutPieper,MarkusCornberg,HeinerWedemeyer,BenjaminHeidrich
Pages:72-82
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DualAgonistofFarnesoidXReceptorandTakedaGProtein-CoupledReceptor5InhibitsHepatitisBVirusInfectionInVitroandInVivo
FarnesoidX受体和武田G蛋白偶联受体5的双重激动剂在体外和体内抑制乙型肝炎病*感染
KiyoakiIto,AkinoriOkumura,JunkoS.Takeuchi,KoichiWatashi,RiekoInoue,TaekoYamauchi,KazumasaSakamoto,YukikoYamashita,YusukeIguchi,MizuhoUne,TakajiWakita,KazuoUmezawa,MasashiYoneda
Pages:83-98
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CharacterizationandApplicationofPrecore/Core-RelatedAntigensinAnimalModelsofHepatitisBVirusInfection
Precore/Core相关抗原在乙型肝炎病*感染动物模型中的表征和应用
XupengHong,LaurieLuckenbaugh,DavidPerlman,PeterA.Revill,StefanF.Wieland,StephanMenne,JianmingHu
Pages:99-
Steatohepatitis/MetabolicLiverDisease（脂肪性肝炎/代谢性肝病）
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Myeloid-Cell–SpecificIL-6SignalingPromotesMicroRNA--EnrichedExosomeProductiontoAttenuateNAFLD-AssociatedFibrosis
髓样细胞特异性IL-6信号传导促进富含MicroRNA-的外泌体产生以减轻NAFLD相关纤维化
XinHou,ShiYin,RuixueRen,SiqiLiu,LiangYong,YuxiaoLiu,YuLi,Ming-HuaZheng,GeorgeKunos,BinGao,HuaWang
Pages:-
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AMachineLearningApproachEnablesQuantitativeMeasurementofLiverHistologyandDiseaseMonitoringinNASH
机器学习方法可在NASH中实现肝脏组织学的定量测量和疾病监测
AmaroTaylor-Weiner,HarshaPokkalla,LingHan,CatherineJia,RyanHuss,ChuhanChung,HunterElliott,BenjaminGlass,KishalvePethia,OscarCarrasco-Zevallos,ChinmayShukla,UrmilaKhettry,RobertNajarian,RossTaliano,G.ManiSubramanian,RobertP.Myers,IlanWapinski,AdityaKhosla,MurrayResnick,MichaelC.Montalto,QuentinM.Anstee,VincentWai-SunWong,MichaelTrauner,EricJ.Lawitz,StephenA.Harrison,TakeshiOkanoue,ManuelRomero-Gomez,ZacharyGoodman,RohitLoomba,AndrewH.Beck,ZobairM.Younossi
Pages:-
14
MetabolicLandscapeoftheMouseLiverbyQuantitative31PNuclearMagneticResonanceAnalysisofthePhosphorome
通过荧光体的定量31P核磁共振分析小鼠肝脏的代谢景观
GanekoBernardo-Seisdedos,JonBilbao,DavidFernández-Ramos,FernandoLopitz-Otsoa,VirginiaGutierrezdeJuan,MaiderBizkarguenaga,BorjaMateos,MarcosF.Fondevila,JordiAbril-Fornaguera,TammoDiercks,ShellyC.Lu,RubénNogueiras,JoséM.Mato,OscarMillet
Pages:-
15
MastCellsPromoteNonalcoholicFattyLiverDiseasePhenotypesandMicrovesicularSteatosisinMiceFedaWesternDiet
肥大细胞促进西方饮食小鼠的非酒精性脂肪肝病表型和微泡性脂肪变性
LindseyKennedy,VikMeadows,AmeliaSybenga,JenniferDemieville,LixianChen,LauraHargrove,BurcinEkser,WasimDar,LudovicaCeci,DebjyotiKundu,KonstantinaKyritsi,LinhPham,TianhaoZhou,ShannonGlaser,FanyinMeng,GianfrancoAlpini,HeatherFrancis
Pages:-
HepatobiliaryMalignancies（肝胆恶性肿瘤）
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DNAMethylationProfilingofHumanHepatocarcinogenesis
人类肝癌发生的DNA甲基化分析
GabrielaHernandez-Meza,JohannvonFelden,EdgarE.Gonzalez-Kozlova,TeresaGarcia-Lezana,JuditPeix,AnnaPortela,AmandaJ.Craig,SergiSayols,MyronSchwartz,BojanLosic,VincenzoMazzaferro,ManelEsteller,JosepM.Llovet,AugustoVillanueva
Pages:-
17
ImmunosuppressiveDrug-ResistantArmoredT-CellReceptorTCellsforImmuneTherapyofHCCinLiverTransplantPatients
用于肝移植患者HCC免疫治疗的免疫抑制药物抗性装甲T细胞受体T细胞
MortezaHafezi,MeiyinLin,AdelineChia,AliciaChua,ZiZongHo,RoyceFam,DamienTan,JoeyAw,AndreaPavesi,ThineshLeeKrishnamoorthy,WanChengChow,WenjieChen,QiZhang,Lu-EnWai,SareneKoh,AnthonyT.Tan,AntonioBertoletti
Pages:-
18
H19PromotesHCCBoneMetastasisThroughReducingOsteoprotegerinExpressioninaProteinPhosphatase1CatalyticSubunitAlpha/p38Mitogen-ActivatedProteinKinase–DependentMannerandSpongingmicroRNAb-3p
H19通过减少蛋白磷酸酶1催化亚基Alpha/p38丝裂原活化蛋白激酶依赖方式和海绵状microRNAb-3p中骨保护素的表达来促进HCC骨转移
ZhaoHuang,LiangChu,JunnanLiang,XiaolongTan,YuWang,JingyuanWen,JinChen,YuWu,ShaLiu,JingyuLiao,RuiHou,ZeyangDing,ZhanguoZhang,HuifangLiang,ShashaSong,CaihongYang,JinmingZhang,TaoGuo,XiaopingChen,BixiangZhang
Pages:-
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TargetingtheDeNovoPurineSynthesisPathwayThroughAdenylosuccinateLyaseDepletionImpairsLiverCancerGrowthbyPerturbingMitochondrialFunction
瞄准从头通过扰乱线粒体功能的嘌呤合成路径通过腺苷酸裂解酶消耗损害肝癌生长
TingtingJiang,FranciscoJ.Sánchez-Rivera,YadiraM.Soto-Feliciano,QiyuanYang,Chun-QingSong,ArjunBhuatkar,ColeMHaynes,MichaelT.Hemann,WenXue
Pages:-
20
OverexpressionofMothersAgainstDecapentaplegicHomolog7ActivatestheYes-AssociatedProtein/NOTCHCascadeandPromotesLiverCarcinogenesisinMiceandHumans
母亲对Decapentaplegic同源物7的过度表达激活Yes相关蛋白/NOTCH级联并促进小鼠和人类的肝癌发生
HaichuanWang,XinhuaSong,HaotianLiao,PanWang,YiZhang,LiChe,JieZhang,YiZhou,AntonioCigliano,CindyAment,DaphneSuperville,SilviaRibback,MelissaReeves,GiovanniM.Pes,BinyongLiang,HongWu,MatthiasEvert,DiegoF.Calvisi,YongZeng,XinChen
Pages:-
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MutationalSignatureAnalysisRevealsWidespreadContributionofPyrrolizidineAlkaloidExposuretoHumanLiverCancer
突变特征分析揭示吡咯里西啶生物碱暴露对人类肝癌的广泛贡献
YishengHe,MaiShi,XuWu,JiangMa,KevinTak-PanNg,QingsuXia,LinZhu,PeterPi-ChengFu,KwanMan,StephenKwok-WingTsui,GeLin
Pages:-
Autoimmune,CholestaticandBiliaryDisease（自身免疫、胆汁淤积和胆道疾病）
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BileAcidProfilesinPrimarySclerosingCholangitisandTheirAbilitytoPredictHepaticDe